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KMID : 0624620210540110551
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BMB Reports
2021 Volume.54 No. 11 p.551 ~ p.556
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Investigation of the effect of Staufen1 overexpression on the HIV-1 virus production
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Park Seong-Won
Yu Kyung-Lee
Bae Jun-Hyun
Kim Ga-Na
Kim Hae-In
You Ji-Chang
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Abstract
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In this study, we investigated how Staufen1 influences the HIV-1 production. The overexpression of Staufen1 increased virus production without any negative affect on the viral infectivity. This increase was not caused by transcriptional activation; but by influencing post-transcriptional steps. Using multiple Gag protein derivatives, we confirmed that the zinc-finger domains of the HIV-1 nucleocapsid (NC) are important for its interaction with Staufen1. We also found that Staufen1 colocalized in stress granules with the mature form of the HIV-1 NC protein.
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KEYWORD
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HIV-1, RNA-binding proteins, Staufen1, Virus-host interaction, Virus replication
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